国产精华推荐2021,欧美性BBBBBXXXXXXX,国产乱妇无乱码大黄aa片,国产97在线 | 中文

當前位置:首頁  >  技術(shù)文章  >  利用負載阿霉素的金屬有機框架涂層磁性納米顆粒精準治療結(jié)腸癌

利用負載阿霉素的金屬有機框架涂層磁性納米顆粒精準治療結(jié)腸癌

更新時間:2025-01-27  |  點擊率:53

20249月,浙江大學材料科學與工程學院;伊利諾伊大學芝加哥分校藥學院藥學系;浙江大學動物科學學院應用生物資源研究所,浙江蠶蜂資源利用與創(chuàng)新重點實驗室 (School of Materials Science &Engineering,Zhejiang University, Hangzhou, Zhejiang 310027, ChinaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, 60607, United States;Key Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang Province,Institute of Applied Bioresource Research, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310058,China;) Honglin Jiang老師研究團隊在《Acs Applied Materials & Interfaces》上發(fā)表論文:

Precision Treatment of Colon Cancer Using Doxorubicin-Loaded Metal-Organic-Framework-Coated Magnetic Nanoparticles"

 

“利用負載阿霉素的金屬有機框架涂層磁性納米顆粒精準治療結(jié)腸癌"

 

Abstract

Due to the limited efficacy and evident side effects of traditional chemotherapy drugs attributed to their lack of specificity and selectivity, novel strategies are essential for improving cancer treatment outcomes. Here, we successfully engineered Fe3O4 magnetic nanoparticles coated with zeolitic imidazolate framework-8 (ZIF-8). The resulting nanocomposite (Fe3O4@ZIF-8) demonstrates efficient adsorption of a substantial amount of doxorubicin (DOX) due to the porous nature of ZIF-8. The drug-loaded nanoparticles, Fe3O4@ZIF-8/DOX, exhibit significant accumulation at the tumor site in SW620 colon-cancer-bearing mice when guided by an external magnetic field. Within the acidic microenvironment of the tumor, the ZIF-8 framework collapses, releasing DOX and effectively inducing tumor cell death, thereby inhibiting cancer progression while not causing undesired side effects, as confirmed by a variety of in vitro and in vivo characterizations. In comparison to free DOX, Fe3O4@ZIF-8/DOX nanoparticles show superior efficacy in colon cancer treatment. Our findings suggest that Fe3O4@ZIF-8 holds promise as a carrier for small-molecule drug adsorption and its ferromagnetic properties provide drug targeting capabilities, thereby enhancing therapeutic effects on tumors at the same drug dosage. With excellent biocompatibility, Fe3O4@ZIF-8 demonstrates potential as a drug carrier in targeted cancer chemotherapy. Our work suggests that a combination of magnetic targeting and acid-responsiveness holds great promise for advancing targeted cancer therapy in precision nanomedicine.


摘要:

由于傳統(tǒng)化療藥物缺乏特異性和選擇性,其療效有限,副作用明顯,因此新的策略對于改善癌癥治療效果至關(guān)重要。在這里,我們成功地設計了包裹有沸石咪唑酸框架-8 ZIF-8)的Fe3O4磁性納米顆粒。由于ZIF-8的多孔性,所得到的納米復合材料(Fe3O4@ZIF-8)能夠有效吸附大量的阿霉素(DOX)。負載藥物的納米顆粒Fe3O4@ZIF-8/DOX在外部磁場引導下,在SW620結(jié)腸癌小鼠的腫瘤部位表現(xiàn)出顯著的積累。在腫瘤的酸性微環(huán)境中,ZIF-8框架崩潰,釋放DOX并有效誘導腫瘤細胞死亡,從而抑制癌癥進展,同時不會引起不良副作用,這一點得到了各種體外和體內(nèi)表征的證實。與游離DOX相比,Fe3O4@ZIF-8/DOX納米顆粒在結(jié)腸癌治療中表現(xiàn)出療效。我們的研究結(jié)果表明,Fe3O4@ZIF-8有望成為小分子藥物吸附的載體,其鐵磁特性提供了藥物靶向能力,從而在相同藥物劑量下增強對腫瘤的治療效果。Fe3O4@ZIF-8具有良好的生物相容性,具有作為靶向癌癥化療藥物載體的潛力。我們的工作表明,磁性靶向和酸反應性的結(jié)合對于推進精確納米醫(yī)學中的靶向癌癥治療具有很大的希望。

 

該論文中,SW620的體外培養(yǎng)是使用Ausbian特級胎牛血清完成的。


亚洲精品国产偷五月天丁香| 八戒八戒神马影院在线观看5| 人妻[21p]大胆| 偷窥 自由 网络 视频| 三a级做爰片免费观看| 国产综合精品| 免费国产黄网站在线观看动图| 亚洲色丰满少妇高潮18p| 日韩精品无码一本二本三本| 国产95在线 | 欧美| 日韩精品无码人成视频手机| 菠萝蜜视频网站| 无码AⅤ精品一区二区三区浪潮| 精品无码三级在线观看视频| 国产真人无码作爱免费视频久| 久久久久久久久久久国产| 日本丰满少妇bbb视频| 无码人妻丰满熟妇区五十路百度| 亚洲精品无码你懂的网站| 欧美VIVO2018| 无人区乱码一区二区三区| 亚洲中文字幕无码中字| 日本一区二区三区视频| 国产精品久久国产精品99| 欧美男男大粗吊1069| 精品国产av一区二区三区| 国产18禁黄网站免费观看| 久久久久亚洲AV成人片一区| 狠狠躁夜夜躁av网站中文字幕| 亚洲av无码精品色午夜app| 性欧美18-19sex性高清播放| 亚洲欧日产| 国产一区二区在线视频| 老熟妇高潮一区二区三区| 中文无码一区二区三区在线观看 | 两个人看的www高清免费中文 | 亚洲啪av永久无码精品放毛片| 嫩草院一区二区乱码| 久久久久人妻精品一区三寸| 18以下岁禁止1000部免费| 啦啦啦资源在线观看视频|