国产精华推荐2021,欧美性BBBBBXXXXXXX,国产乱妇无乱码大黄aa片,国产97在线 | 中文

當(dāng)前位置:首頁  >  技術(shù)文章  >  RGDSP功能化肽水凝膠,促進(jìn)人羊膜間充質(zhì)干細(xì)胞創(chuàng)面愈合

RGDSP功能化肽水凝膠,促進(jìn)人羊膜間充質(zhì)干細(xì)胞創(chuàng)面愈合

更新時(shí)間:2025-01-27  |  點(diǎn)擊率:72

202410月,貴州省細(xì)胞工程重點(diǎn)實(shí)驗(yàn)室,遵義醫(yī)學(xué)院附屬醫(yī)院,遵義醫(yī)科大學(xué)附屬醫(yī)院臨床干細(xì)胞研究所,湖北醫(yī)科大學(xué)附屬太和醫(yī)院創(chuàng)面修復(fù)與皮膚外科 (Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China,The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China,Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China) Wei Wei老師研究團(tuán)隊(duì)在《Frontiers in Bioengineering and Biotechnology》上發(fā)表論文:

RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells"

 

RGDSP功能化肽水凝膠通過整合素αv/PI3K/AKT軸刺激生長因子分泌,促進(jìn)人羊膜間充質(zhì)干細(xì)胞創(chuàng)面愈合"

 

Abstract

The wound healing process involves communication among growth factors, cytokines, signaling pathways, and cells in the extracellular matrix, with growth factors acting as key regulators. Although stem cells can promote wound healing by secreting diverse growth factors, their therapeutic potential is hindered by poor survival and engraftment. Mimicking the stem cell-matrix interactions can improve stem cell survival, regulate their fate, and even enhance their paracrine effects. This study investigated the use of composite RGDmix hydrogel, which can support the survival and proliferation of human amniotic mesenchymal stem cells (hAMSCs), and effectively increase the expression of various growth factors, thereby promoting wound re-epithelialization, angiogenesis, and epidermal maturation. At last, the specific role of integrin αv and PI3K/AKT signaling pathways in the secretion of growth factors were examined by silencing them in vitro and in vivo. Results suggested that the RGDmix hydrogel improved the secretion of growth factors by hAMSCs through the RGDSP/integrin αv/PI3K/AKT axis, thereby enhancing the therapeutic effect in wound healing.


摘要:

傷口愈合過程涉及生長因子、細(xì)胞因子、信號(hào)通路和細(xì)胞外基質(zhì)細(xì)胞之間的交流,其中生長因子是關(guān)鍵的調(diào)節(jié)因子。雖然干細(xì)胞可以通過分泌多種生長因子促進(jìn)傷口愈合,但其治療潛力受到生存和植入性差的阻礙。模擬干細(xì)胞與基質(zhì)的相互作用可以提高干細(xì)胞的存活率,調(diào)節(jié)其命運(yùn),甚至增強(qiáng)其旁分泌作用。本研究研究了復(fù)合RGDmix水凝膠能夠支持人羊膜間充質(zhì)干細(xì)胞(hAMSCs)的存活和增殖,并有效增加各種生長因子的表達(dá),從而促進(jìn)創(chuàng)面再上皮化、血管生成和表皮成熟。最后,通過體外和體內(nèi)實(shí)驗(yàn),研究整合素αvPI3K/AKT信號(hào)通路在生長因子分泌中的具體作用。結(jié)果表明,RGDmix水凝膠通過RGDSP/integrin αv/PI3K/AKT軸促進(jìn)hAMSCs分泌生長因子,從而增強(qiáng)傷口愈合的治療效果。

 

該論文中,hAMSCs的體外培養(yǎng)是使用Ausbian特級(jí)胎牛血清完成的。


精品久久久无码中文字幕| 久久夜色精品国产亚洲AV动态图 | 国产无遮挡吃奶视频网站| 自拍偷在线精品自拍偷无码专区| 久久理论片午夜琪琪电影网| 人妻被按摩师玩弄到潮喷| 国产精品久久人妻拍拍水牛影视 | 日本又色又爽又黄又免费网站| 最近2019中文字幕大全第二页| 97porm国内自拍视频| 中国国语毛片免费观看视频| 成人AV片无码免费网站| 天堂网在线观看| 88国产精品视频一区二区三区| 亚洲永久精品ww47| 欧美性大战久久久久xxx| 在线天堂中文最新版网| 孩交精品xxxx视频视频| 无码国产69精品久久久久APP| 一个人在线观看的www片| 无码专区狠狠躁躁天天躁| 欧美FREESEX黑人又粗又大 | 久久久久亚洲av成人网| 成人免费在线电影| 蜜桃av抽搐高潮一区二区| 欧美亚洲国产精品久久高清| 久久aaaa片一区二区| 欧美日韩亚洲国产精品| 欧美性猛交╳xxx富婆 | 特黄A片在线播放免费麻婆豆腐| 一本到高清视频不卡dvd| 亚洲午夜福利AV一区二区无码| 丰满少妇做爰视频爽爽和| 野花香高清在线观看视频播放免费| 国产精品人人妻人色五月| av精品一区二区三区| 中文字幕一区二区三区日韩精品 | 无码人妻久久一区二区三区免费丨| 亚洲国产成人精品无码区在线| 亚洲一久久久久久久久| 日本久久久久久久久精品|