国产精华推荐2021,欧美性BBBBBXXXXXXX,国产乱妇无乱码大黄aa片,国产97在线 | 中文

當前位置:首頁  >  技術文章  >  CDK11需要一個關鍵的激活子SAP30BP來調(diào)節(jié)pre-mRNA剪接

CDK11需要一個關鍵的激活子SAP30BP來調(diào)節(jié)pre-mRNA剪接

更新時間:2024-12-28  |  點擊率:102

202312月,中國科學院分子細胞科學研究中心;中國科學院上海生物化學與細胞生物學研究所;中國科學院RNA科學與工程重點實驗室;武漢大學生命科學學院;太康生命與醫(yī)學科學中心;RNA研究所;湖北省細胞穩(wěn)態(tài)重點實驗室;中國科學院分析化學分離科學重點實驗室;武漢中國科學院大連化學物理研究所國家色譜研究中心;中國科學院大學杭州高等研究院生命科學學院浙江省系統(tǒng)健康科學重點實驗室(Key Laboratory of RNA Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China;College of Life Sciences, TaiKang Center for Life and Medical Sciences, RNA Institute, Hubei Key Laboratory of Cell Homeostasis, Wuhan University, Wuhan, China;CAS Key Laboratory of Separation Sciences for Analytical Chemistry,  National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, ChinaKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences,Hangzhou, China) Jing Fan老師研究團隊在《The EMBO Journal》上發(fā)表論文:

CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing"

 

CDK11需要一個關鍵的激活子SAP30BP來調(diào)節(jié)pre-mRNA剪接"

 

Abstract

CDK11 is an emerging druggable target for cancer therapy due to its prevalent roles in phosphorylating critical transcription and splicing factors and in facilitating cell cycle progression in cancer cells. Like other cyclin-dependent kinases, CDK11 requires its cognate cyclin, cyclin L1 or cyclin L2, for activation. However, little is known about how CDK11 activities might be modulated by other regulators. In this study, we show that CDK11 forms a tight complex with cyclins L1/L2 and SAP30BP, the latter of which is a poorly characterized factor. Acute degradation of SAP30BP mirrors that of CDK11 in causing widespread and strong defects in pre-mRNA splicing. Furthermore, we demonstrate that SAP30BP facilitates CDK11 kinase activities in vitro and in vivo, through ensuring the stabilities and the assembly of cyclins L1/L2 with CDK11. Together, these findings uncover SAP30BP as a critical CDK11 activator that regulates global pre-mRNA splicing.


摘要:

CDK11是一個新興的癌癥治療藥物靶點,因為它在磷酸化關鍵轉錄和剪接因子以及促進癌細胞細胞周期進程中發(fā)揮著普遍作用。像其他細胞周期蛋白依賴性激酶一樣,CDK11需要其同源細胞周期蛋白,細胞周期蛋白L1或細胞周期蛋白L2來激活。然而,對于CDK11的活性如何被其他調(diào)節(jié)因子調(diào)節(jié),研究人員所知甚少。在這項研究中,研究人員發(fā)現(xiàn)CDK11與細胞周期蛋白L1/L2SAP30BP形成緊密復合物,后者是一個特征不明顯的因子。SAP30BP的急性降解與CDK11一樣,在pre-mRNA剪接中引起廣泛而強烈的缺陷。此外,研究人員證明SAP30BP通過確保細胞周期蛋白L1/L2CDK11的穩(wěn)定性和組裝,促進了CDK11激酶在體外和體內(nèi)的活性。綜上所述,這些發(fā)現(xiàn)揭示了SAP30BP作為一個關鍵的CDK11激活因子,調(diào)控全局pre-mRNA剪接。

 

該論文中,HeLa HAP1細胞的體外培養(yǎng)是使用Ausbian特級胎牛血清完成的。


欧美噜噜久久久XXX| 撸啊撸视频在线观看| 人妻无码中文字幕免费视频蜜桃| 女人被强╳到高潮喷水在线观看 | 两个人看的www视频免费完整版 | 国产精品久久久久9999无码| 精品无码久久久久国产| 人妻体验按摩调情BD| 色欲AV自慰一区二区三区| 给我免费播放片在线| 国产女人乱人伦精品一区二区| 久久国产精品久久喷水| 国产精品理论片在线观看| 少女动漫在线高清免费观看| 国产熟妇无码a片aaa毛片视频 | ass日本熟妇大全pic| 一个人看的日本www| 亚洲欧洲自拍拍偷精品 美利坚 | 蜜臀AV性久久久久蜜臀AⅤ麻豆| 精品亚洲一区二区三区四区五区 | 久久综合噜噜激激的五月天| 亚洲AV无码无在线观看 | 深夜a级毛片免费无码| 三级国产三级在线| 亚洲av无码成人精品区| 精品久久久久久无码人妻热 | 精品露脸国产偷人在视频| 丰满少妇作爱视频免费观看| 波野吉多结衣在线观看| 蜜桃AV无码免费看永久| 性做久久久久久| 欧美精品久久久久a片色戒| 9277在线观看免费播放| 欧美大屁股xxxxhd黑色| 久久天天躁狠狠躁夜夜96流白浆| 亚洲av无码一区二区三区在线| 亚洲av无码一区二区二三区| 亚洲AV色欲色欲WWW| a片毛片免费无限观看| 亚洲精品中文字幕无码蜜桃| 麻豆视传媒官网免费观看 |